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| カタログ番号 | HF993014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-H6PD Polyclonal Antibody (HF993014) is a rabbit polyclonal antibody detecting H6PD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human H6PD (Gln20-Gln526). | ||||||||
| ターゲット | GDH, 6PGL, Glucose 1-dehydrogenase, H6PD, Glucose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95479 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | GDH/6PGL endoplasmic bifunctional protein (H6PD) is a ~88 kDa protein. Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. 1. Draper, N. et al. (2003) Nature genetics 34, 434-9. PMID: 12858176 2. Lavery, GG. et al. (2008) The Journal of clinical endocrinology and metabolism 93, 3827-32. PMID: 18628520 3. Lavery, GG. et al. (2013) European journal of endocrinology 168, K19-26. PMID: 23132696 | ||||||||
| 注意事項 | For research use only. |
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