Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064)

Name: Anti-HAdV-41 E1B-55K Polyclonal Antibody
Brand: abinScience
SKU: VK466064
Price: 168 USD
Availability: InStock

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50ug
100ug

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

VK466064

Description

Anti-HAdV-41 E1B-55K Polyclonal Antibody (VK466064) is a rabbit polyclonal antibody detecting E1B-55K in ELISA, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Reactivité des espèces

Human adenovirus E serotype 41 (HAdV-41)

Applications

ELISA, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant HAdV-41 E1B-55K (Lys98-Asp472).

Cible

E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R

Purification

Purified by antigen affinity column.

Numéro d'accès

P10546

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

E1B 55 kDa protein (E1B-55K) is a ~52 kDa protein. Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. E1B-55K probably acts as the substrate-specific adapter of the SCF-like E3 ubiquitin ligase complex. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.

Note

For research use only.

Images

Reférences

Fiche technique

Anti-HAdV-41 E1B-55K Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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