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Anti-HAdV-5 E1B-55K Polyclonal Antibody (VK466084)

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Número de catálogoVK466084
Descripción
Anti-HAdV-5 E1B-55K/E1B-495R Polyclonal Antibody (VK466084) is a rabbit polyclonal antibody detecting E1B-495R in ELISA, IHC, WB.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman adenovirus C serotype 2 (HAdV-2), Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant HAdV-5 E1B-55K/E1B-495R (Lys138-Val426).
Objetivo E1B 55 kDa protein, E1B-55K, E1b55K, E1B protein, large T-antigen, E1B-495R
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P03243, P03244
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000,IHC:1:50-1:500,WB:1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

E1B 55 kDa protein (E1B-55K/E1B-495R) is a ~55 kDa protein. Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6. This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM. E1B-55K probably acts as the substrate-specific adapter of the SCF-like E3 ubiquitin ligase complex. Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.

1. Harada, JN. et al. (2002) Journal of virology 76, 9194-206. PMID: 12186903
2. Carson, CT. et al. (2003) The EMBO journal 22, 6610-20. PMID: 14657032
3. Schwartz, RA. et al. (2008) Journal of virology 82, 9043-55. PMID: 18614635
4. Schreiner, S. et al. (2010) Journal of virology 84, 7029-38. PMID: 20484509
5. Pennella, MA. et al. (2010) Journal of virology 84, 12210-25. PMID: 20861261
6. Wimmer, P. et al. (2016) Oncogene 35, 69-82. PMID: 25772236
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Mass
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Volume
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g/mol
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C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-HAdV-5 E1B-55K Polyclonal Antibody

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