

| Numéro de catalogue | VK764014 | ||||||||
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| Description |
Anti-HAdV-5 Fiber protein/L5 Polyclonal Antibody (VK764014) is a rabbit polyclonal antibody detecting Fiber protein in ELISA, WB.
Highlights
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| Reactivité des espèces | Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) | ||||||||
| Applications | ELISA, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant HAdV-5 Fiber protein/L5 (Gly387-Glu581). | ||||||||
| Cible | Fiber protein, SPIKE, Protein IV, L5 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P11818 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Fiber protein (L5) is a ~61 kDa protein. Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. | ||||||||
| Note | For research use only. |
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