Anti-HDAC1 Polyclonal Antibody (HC626014)

Name: Anti-HDAC1 Polyclonal Antibody
Brand: abinScience
SKU: HC626014
Price: 96 USD
Availability: InStock

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Vista general

Número de catálogo

HC626014

Descripción

Anti-HDAC1 Polyclonal Antibody (HC626014) is a rabbit polyclonal antibody detecting HDAC1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human HDAC1 (Val183-Ala482).

Objetivo

Histone deacetylase 1, HDAC1, RPD3L1, HD1

Purificación

Purified by antigen affinity column.

Número de acceso

Q13547

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Histone deacetylase 1 (HDAC1) is a ~55 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.

1. Qiu, Y. et al. (2006) Molecular cell 22, 669-79. PMID: 16762839

2. Wang, C. et al. (2007) The Journal of biological chemistry 282, 29902-9. PMID: 17704056

3. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

4. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 16428440

5. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666

6. Jelinic, P. et al. (2011) Molecular and cellular biology 31, 54-62. PMID: 21041482

8. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

9. Zheng, G. et al. (2006) Biochemical and biophysical research communications 339, 1069-75. PMID: 16337145

10. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-HDAC1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: HepG2 cell lysate