Anti-HDAC1 Polyclonal Antibody (HC626024)

Name: Anti-HDAC1 Polyclonal Antibody
Brand: abinScience
SKU: HC626024
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HC626024

Description

Anti-HDAC1 Polyclonal Antibody (HC626024) is a rabbit polyclonal antibody detecting HDAC1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human HDAC1 (Met1-Ala482).

Cible

Histone deacetylase 1, HDAC1, RPD3L1, HD1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13547

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Histone deacetylase 1 (HDAC1) is a ~55 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.

1. Qiu, Y. et al. (2006) Molecular cell 22, 669-79. PMID: 16762839

2. Wang, C. et al. (2007) The Journal of biological chemistry 282, 29902-9. PMID: 17704056

3. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

4. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 16428440

5. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666

6. Jelinic, P. et al. (2011) Molecular and cellular biology 31, 54-62. PMID: 21041482

8. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

9. Zheng, G. et al. (2006) Biochemical and biophysical research communications 339, 1069-75. PMID: 16337145

10. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997

Note

For research use only.

Images

Reférences

Fiche technique

Anti-HDAC1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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