Anti-HDAC1 Polyclonal Antibody (HC626024)

Name: Anti-HDAC1 Polyclonal Antibody
Brand: abinScience
SKU: HC626024
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HC626024

Описание

Anti-HDAC1 Polyclonal Antibody (HC626024) is a rabbit polyclonal antibody detecting HDAC1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human HDAC1 (Met1-Ala482).

Цель

Histone deacetylase 1, HDAC1, RPD3L1, HD1

Очистка

Purified by antigen affinity column.

Номер доступа

Q13547

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Histone deacetylase 1 (HDAC1) is a ~55 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.

1. Qiu, Y. et al. (2006) Molecular cell 22, 669-79. PMID: 16762839

2. Wang, C. et al. (2007) The Journal of biological chemistry 282, 29902-9. PMID: 17704056

3. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

4. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 16428440

5. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666

6. Jelinic, P. et al. (2011) Molecular and cellular biology 31, 54-62. PMID: 21041482

8. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960

9. Zheng, G. et al. (2006) Biochemical and biophysical research communications 339, 1069-75. PMID: 16337145

10. Hung, JJ. et al. (2006) Molecular and cellular biology 26, 1770-85. PMID: 16478997

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-HDAC1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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