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Anti-HDAC6 Polyclonal Antibody (HV287014)

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Vista general
Número de catálogoHV287014
Descripción
Anti-HDAC6 Polyclonal Antibody (HV287014) is a rabbit polyclonal antibody detecting HDAC6 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human HDAC6 (Ser479-Arg835).
Objetivo KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6
Purificación Purified by antigen affinity column.
Número de acceso Q9UBN7
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Protein deacetylase HDAC6 is a ~131 kDa protein. Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy.

1. Hubbert, C. et al. (2002) Nature 417, 455-8. PMID: 12024216
2. Parmigiani, RB. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9633-8. PMID: 18606987
3. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065
4. Zhang, M. et al. (2014) Molecular cell 55, 31-46. PMID: 24882211
5. Ran, J. et al. (2015) Scientific reports 5, 12917. PMID: 26246421
6. Wang, R. et al. (2019) The Journal of cell biology 218, 267-284. PMID: 30538141
7. You, Z. et al. (2019) Nature communications 10, 5792. PMID: 31857589
8. Zhang, M. et al. (2019) The Journal of biological chemistry 294, 5813-5826. PMID: 30770470
9. Sun, C. et al. (2024) Cells 13. PMID: 38534334
10. Jin, J. et al. (2025) Nature 637, 215-223. PMID: 39567688
Nota For research use only.
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-HDAC6 Polyclonal Antibody

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