中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HV287014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HDAC6 Polyclonal Antibody (HV287014) is a rabbit polyclonal antibody detecting HDAC6 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HDAC6 (Ser479-Arg835). | ||||||||
| ターゲット | KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UBN7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein deacetylase HDAC6 is a ~131 kDa protein. Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. 1. Hubbert, C. et al. (2002) Nature 417, 455-8. PMID: 12024216 2. Parmigiani, RB. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9633-8. PMID: 18606987 3. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065 4. Zhang, M. et al. (2014) Molecular cell 55, 31-46. PMID: 24882211 5. Ran, J. et al. (2015) Scientific reports 5, 12917. PMID: 26246421 6. Wang, R. et al. (2019) The Journal of cell biology 218, 267-284. PMID: 30538141 7. You, Z. et al. (2019) Nature communications 10, 5792. PMID: 31857589 8. Zhang, M. et al. (2019) The Journal of biological chemistry 294, 5813-5826. PMID: 30770470 9. Sun, C. et al. (2024) Cells 13. PMID: 38534334 10. Jin, J. et al. (2025) Nature 637, 215-223. PMID: 39567688 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
