Anti-HDAC8 Polyclonal Antibody (HV385014)

Name: Anti-HDAC8 Polyclonal Antibody
Brand: abinScience
SKU: HV385014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HV385014

Description

Anti-HDAC8 Polyclonal Antibody (HV385014) is a rabbit polyclonal antibody detecting HDAC8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human HDAC8 (Met1-Val377).

Cible

HDAC8, Histone deacetylase 8, HD8, HDACL1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9BY41

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Histone deacetylase 8 (HDAC8) is a ~41 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

1. Hu, E. et al. (2000) The Journal of biological chemistry 275, 15254-64. PMID: 10748112

2. Van den Wyngaert, I. et al. (2000) FEBS letters 478, 77-83. PMID: 10922473

3. Buggy, JJ. et al. (2000) The Biochemical journal 350 Pt 1, 199-205. PMID: 10926844

4. Lee, H. et al. (2004) Molecular and cellular biology 24, 765-73. PMID: 14701748

5. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

Note

For research use only.

Images

Reférences

Fiche technique

Anti-HDAC8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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