Anti-HDAC8 Polyclonal Antibody (HV385014)

Name: Anti-HDAC8 Polyclonal Antibody
Brand: abinScience
SKU: HV385014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HV385014

Описание

Anti-HDAC8 Polyclonal Antibody (HV385014) is a rabbit polyclonal antibody detecting HDAC8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human HDAC8 (Met1-Val377).

Цель

HDAC8, Histone deacetylase 8, HD8, HDACL1

Очистка

Purified by antigen affinity column.

Номер доступа

Q9BY41

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Histone deacetylase 8 (HDAC8) is a ~41 kDa protein. Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

1. Hu, E. et al. (2000) The Journal of biological chemistry 275, 15254-64. PMID: 10748112

2. Van den Wyngaert, I. et al. (2000) FEBS letters 478, 77-83. PMID: 10922473

3. Buggy, JJ. et al. (2000) The Biochemical journal 350 Pt 1, 199-205. PMID: 10926844

4. Lee, H. et al. (2004) Molecular and cellular biology 24, 765-73. PMID: 14701748

5. Wei, W. et al. (2017) Cell research 27, 898-915. PMID: 28497810

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-HDAC8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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