Anti-HEV ORF3 Recombinant Antibody (SAA2695) (VK620073)

Name: Anti-HEV ORF3 Recombinant Antibody (SAA2695)
Brand: abinScience
SKU: VK620073
Price: 191 USD
Availability: InStock

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Numéro de catalogue	VK620073
Reactivité des espèces	Hepatitis E virus (HEV)
Applications	ELISA, IF, WB
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1
ID de clone	SAA2695
Cible	Protein ORF3
Niveau d'endotoxines	<10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	E9N3C1
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Protein ORF3 is a ~11 kDa protein. Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Also acts as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways. Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression.
Note	For research use only

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