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| カタログ番号 | HY435014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HEXB Polyclonal Antibody (HY435014) is a rabbit polyclonal antibody detecting HEXB in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HEXB (Lys315-Tyr456). | ||||||||
| ターゲット | N-Acetyl-β-glucosaminidase (NAG), chitobiase, NAG, Beta-hexosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, N-acetyl-beta-glucosaminidase subunit beta, Cervical cancer proto-oncogene 7 protein, Hexosaminidase subunit B, HCC-7, HEXB | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07686 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Beta-hexosaminidase subunit beta (HEXB/HCC7) is a ~63 kDa protein. Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida. 1. Hepbildikler, ST. et al. (2002) The Journal of biological chemistry 277, 2562-72. PMID: 11707436 2. Novak, A. et al. (1994) Biochimica et biophysica acta 1199, 215-23. PMID: 8123671 3. Hou, Y. et al. (1996) Biochemistry 35, 3963-9. PMID: 8672428 4. Hou, Y. et al. (1998) The Journal of biological chemistry 273, 21386-92. PMID: 9694901 | ||||||||
| 注意事項 | For research use only. |
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