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| カタログ番号 | VK595043 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-HHV5/HCMV HHRF3/US28 Nanobody (Nb7) [Nb7] (VK595043) is a alpaca monoclonal antibody detecting HHRF3 in ELISA.
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| 種反応性 | Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-8His | ||||
| クローンID | Nb7 | ||||
| ターゲット | G-protein coupled receptor homolog US28, HHRF3, US28 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by Nickel column. | ||||
| アクセッション番号 | P69332 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling. 1. Burg, JS. et al. (2015) Science (New York, N.Y.) 347, 1113-7. PMID: 25745166 2. Kuhn, DE. et al. (1995) Biochemical and biophysical research communications 211, 325-30. PMID: 7540006 3. Gao, JL. et al. (1994) The Journal of biological chemistry 269, 28539-42. PMID: 7961796 4. Casarosa, P. et al. (2001) The Journal of biological chemistry 276, 1133-7. PMID: 11050102 5. Tsutsumi, N. et al. (2022) Science advances 8, eabl5442. PMID: 35061538 6. Maassen, F. et al. (2025) eLife 14. PMID: 40608405 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-HHV5/HCMV HHRF3/US28 Nanobody (Nb7)
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中国武漢市深敦寺路666号C棟、武漢、430206
