

| Numéro de catalogue | HW500014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human HK2 (Trp619-Arg917). | ||||||||
| Cible | HK II, Hexokinase type II, Hexokinase-2, Hexokinase-B, HK2, Muscle form hexokinase | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P52789 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Hexokinase-2 (HK2) is a ~102 kDa protein. Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. 1. Cheung, EC. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20491-6. PMID: 23185017 2. Lin, H. et al. (2016) ACS medicinal chemistry letters 7, 217-22. PMID: 26985301 3. Nawaz, MH. et al. (2018) Bioscience reports 38. PMID: 29298880 4. Chiara, F. et al. (2008) PloS one 3, e1852. PMID: 18350175 | ||||||||
| Note | For research use only. |
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