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| カタログ番号 | HB755014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HMGB2 Polyclonal Antibody (HB755014) is a rabbit polyclonal antibody detecting HMGB2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Callithrix jacchus, Dog, and Equus caballus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HMGB2 (Gly2-Pro187). | ||||||||
| ターゲット | HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26583 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | High mobility group protein B2 (HMGB2) is a ~24 kDa protein. Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. 1. Fan, Z. et al. (2002) Molecular and cellular biology 22, 2810-20. PMID: 11909973 2. Zimmerman, J. et al. (2008) Biochemical and biophysical research communications 371, 79-84. PMID: 18413230 3. Ugrinova, I. et al. (2009) Biochemistry 48, 6502-7. PMID: 19522541 4. Laurent, B. et al. (2010) Blood 115, 687-95. PMID: 19965638 5. Stros, M. (2010) Biochimica et biophysica acta 1799, 101-13. PMID: 20123072 6. Shykind, BM. et al. (1995) Genes & development 9, 1354-65. PMID: 7797075 7. Pusterla, T. et al. (2009) Autoimmunity 42, 308-10. PMID: 19811285 8. Küchler, R. et al. (2013) Antimicrobial agents and chemotherapy 57, 4782-93. PMID: 23877675 | ||||||||
| 注意事項 | For research use only. |
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