Anti-HMGB2 Polyclonal Antibody (HB755014)

Name: Anti-HMGB2 Polyclonal Antibody
Brand: abinScience
SKU: HB755014
Price: 168 USD
Availability: InStock

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Каталожный номер

HB755014

Описание

Anti-HMGB2 Polyclonal Antibody (HB755014) is a rabbit polyclonal antibody detecting HMGB2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Callithrix jacchus, Dog, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human HMGB2 (Gly2-Pro187).

Цель

HMGB2, High mobility group protein 2, HMG-2, HMG2, High mobility group protein B2

Очистка

Purified by antigen affinity column.

Номер доступа

P26583

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

High mobility group protein B2 (HMGB2) is a ~24 kDa protein. Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity.

1. Fan, Z. et al. (2002) Molecular and cellular biology 22, 2810-20. PMID: 11909973

2. Zimmerman, J. et al. (2008) Biochemical and biophysical research communications 371, 79-84. PMID: 18413230

3. Ugrinova, I. et al. (2009) Biochemistry 48, 6502-7. PMID: 19522541

4. Laurent, B. et al. (2010) Blood 115, 687-95. PMID: 19965638

5. Stros, M. (2010) Biochimica et biophysica acta 1799, 101-13. PMID: 20123072

6. Shykind, BM. et al. (1995) Genes & development 9, 1354-65. PMID: 7797075

7. Pusterla, T. et al. (2009) Autoimmunity 42, 308-10. PMID: 19811285

8. Küchler, R. et al. (2013) Antimicrobial agents and chemotherapy 57, 4782-93. PMID: 23877675

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-HMGB2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-HMGB2 Polyclonal Antibody (HB755014)

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