Anti-HMGCR Polyclonal Antibody (HY041014)

Name: Anti-HMGCR Polyclonal Antibody
Brand: abinScience
SKU: HY041014
Price: 96 USD
Availability: InStock

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SDS

Vista general

Número de catálogo

HY041014

Descripción

Anti-HMGCR Polyclonal Antibody (HY041014) is a rabbit polyclonal antibody detecting HMGCR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cricetulus griseus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human HMGCR (Glu441-Asn875).

Objetivo

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMGCR, HMG-CoA reductase

Purificación

Purified by antigen affinity column.

Número de acceso

P04035

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is a ~97 kDa protein. Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.

1. Cuccioloni, M. et al. (2011) Journal of lipid research 52, 897-907. PMID: 21357570

2. Luskey, KL. et al. (1985) The Journal of biological chemistry 260, 10271-7. PMID: 2991281

3. Yogev, Y. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2217831120. PMID: 36745799

4. Brown, MS. et al. (1980) Journal of lipid research 21, 505-17. PMID: 6995544

5. Istvan, ES. et al. (2001) Science (New York, N.Y.) 292, 1160-4. PMID: 11349148

6. Sarver, RW. et al. (2008) Journal of medicinal chemistry 51, 3804-13. PMID: 18540668

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-HMGCR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo