

| Número de catálogo | HW553014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human HNF4A (Gln131-Ser330). | ||||||||
| Objetivo | Nuclear receptor subfamily 2 group A member 1, HNF-4-alpha, HNF4A, Hepatocyte nuclear factor 4-alpha, NR2A1, TCF14, Transcription factor 14, Transcription factor HNF-4, TCF-14, HNF4 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P41235 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Hepatocyte nuclear factor 4-alpha (HNF4A) is a ~52 kDa protein. Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells. 1. DeLaForest, A. et al. (2018) Genes 10. PMID: 30597922 2. Qu, M. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E12305-E12312. PMID: 30530698 | ||||||||
| Nota | For research use only. |
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