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Anti-HNRNPA2B1 Polyclonal Antibody (HB093014)

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Número de catálogoHB093014
Descripción
Anti-HNRNPA2B1 Polyclonal Antibody (HB093014) is a rabbit polyclonal antibody detecting HNRNPA2B1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human HNRNPA2B1 (Arg21-Gly103).
Objetivo Heterogeneous nuclear ribonucleoproteins A2/B1, HNRPA2B1, hnRNP A2/B1, HNRNPA2B1
Purificación Purified by antigen affinity column.
Número de acceso P22626
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) is a ~37 kDa protein. Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm.

1. He, Y. et al. (2009) Cellular and molecular life sciences : CMLS 66, 1239-56. PMID: 19099192
2. Munro, TP. et al. (1999) The Journal of biological chemistry 274, 34389-95. PMID: 10567417
3. Alarcón, CR. et al. (2015) Cell 162, 1299-308. PMID: 26321680
4. Villarroya-Beltri, C. et al. (2013) Nature communications 4, 2980. PMID: 24356509
5. David, CJ. et al. (2010) Nature 463, 364-8. PMID: 20010808
6. Wang, L. et al. (2019) Science (New York, N.Y.) 365. PMID: 31320558
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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