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| カタログ番号 | HB093014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HNRNPA2B1 Polyclonal Antibody (HB093014) is a rabbit polyclonal antibody detecting HNRNPA2B1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HNRNPA2B1 (Arg21-Gly103). | ||||||||
| ターゲット | Heterogeneous nuclear ribonucleoproteins A2/B1, HNRPA2B1, hnRNP A2/B1, HNRNPA2B1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P22626 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) is a ~37 kDa protein. Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. 1. He, Y. et al. (2009) Cellular and molecular life sciences : CMLS 66, 1239-56. PMID: 19099192 2. Munro, TP. et al. (1999) The Journal of biological chemistry 274, 34389-95. PMID: 10567417 3. Alarcón, CR. et al. (2015) Cell 162, 1299-308. PMID: 26321680 4. Villarroya-Beltri, C. et al. (2013) Nature communications 4, 2980. PMID: 24356509 5. David, CJ. et al. (2010) Nature 463, 364-8. PMID: 20010808 6. Wang, L. et al. (2019) Science (New York, N.Y.) 365. PMID: 31320558 | ||||||||
| 注意事項 | For research use only. |
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