Anti-HPeV-1 VP3 Polyclonal Antibody (VK085024) is a rabbit polyclonal antibody detecting Capsid protein VP3 in ELISA, IHC, WB.
Highlights
●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
Reactividad de especies
Human parechovirus 1 (HPeV-1)
Aplicaciones
ELISA, IHC, WB
Especie huésped
Rabbit
Clonalidad
Polyclonal
Isotipo
IgG
Inmunógeno
E. coli - derived recombinant HPeV-1 Genome polyprotein (Leu361-Gln542).
Objetivo
Genome polyprotein, Capsid protein VP0, P1AB, Virion protein 0, Capsid protein VP3, P1C, Virion protein 3, Capsid protein VP1, P1D, Virion protein 1, Protein 2A H-NC, P2A, Protein 2A, Protein 2B, P2B, Protein 2C, P2C, 3.6.1.15, Protein 3A, P3A, Viral protein genome-linked, VPg, Protein 3B, P3B, Protease 3C, P3C, 3.4.22.28, Picornain 3C, RNA-directed RNA polymerase 3D-POL, P3D-POL, 2.7.7.48
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación
Dilución
ELISA
1:5000-1:20000,IHC:1:50-1:500,WB:1:500-1:2000
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo
Genome polyprotein (VP3) is a ~245 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry together with capsid proteins VP1 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis. Binds packaging signals present in the viral RNA.
1. Joki-Korpela, P. et al. (2001) Journal of virology 75, 1958-67. PMID: 11160695
2. Shakeel, S. et al. (2017) Nature communications 8, 5. PMID: 28232749
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