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| カタログ番号 | HX900014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HSD11B2 Polyclonal Antibody (HX900014) is a rabbit polyclonal antibody detecting HSD11B2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HSD11B2 (Gly106-Arg405). | ||||||||
| ターゲット | HSD11B2, 11-beta-HSD type II, 11-beta-HSD, 11-DH2, Short chain dehydrogenase/reductase family 9C member 3, Corticosteroid 11-beta-dehydrogenase isozyme 2, SDR9C3, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, 11-beta-hydroxysteroid dehydrogenase type II, 11-beta-hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, HSD11K, 11-HSD type II | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P80365 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) is a ~44 kDa protein. Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. 1. Odermatt, A. et al. (1999) The Journal of biological chemistry 274, 28762-70. PMID: 10497248 2. Carvajal, CA. et al. (2003) The Journal of clinical endocrinology and metabolism 88, 2501-7. PMID: 12788846 3. Atanasov, AG. et al. (2007) Journal of the American Society of Nephrology : JASN 18, 1262-70. PMID: 17314322 4. Meyer, A. et al. (2012) Toxicology 301, 72-8. PMID: 22796344 5. Tsachaki, M. et al. (2017) The Journal of endocrinology 232, 323-335. PMID: 27927697 6. Beck, KR. et al. (2019) The Journal of steroid biochemistry and molecular biology 190, 19-28. PMID: 30902677 7. Inderbinen, SG. et al. (2021) Toxicology and applied pharmacology 412, 115387. PMID: 33387577 8. Albiston, AL. et al. (1994) Molecular and cellular endocrinology 105, R11-7. PMID: 7859916 9. Stewart, PM. et al. (1996) Lancet (London, England) 347, 88-91. PMID: 8538347 | ||||||||
| 注意事項 | For research use only. |
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