Anti-HSP90AA1 Polyclonal Antibody (HY503014)

Name: Anti-HSP90AA1 Polyclonal Antibody
Brand: abinScience
SKU: HY503014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HY503014

Description

Anti-HSP90AA1 Polyclonal Antibody (HY503014) is a rabbit polyclonal antibody detecting HSP90AA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human HSP90AA1 (Ser39-Asp193).

Cible

LPS-associated protein 2, Heat shock protein HSP 90-alpha, HSPCA, HSP90A, HSP 86, Lipopolysaccharide-associated protein 2, HSP86, HSP90AA1, Heat shock 86 kDa, Renal carcinoma antigen NY-REN-38, LAP-2, HSPC1

Purification

Purified by antigen affinity column.

Numéro d'accès

P07900

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Heat shock protein HSP 90-alpha (HSP90AA1) is a ~84 kDa protein. Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself.

1. Forsythe, HL. et al. (2001) The Journal of biological chemistry 276, 15571-4. PMID: 11274138

2. Young, JC. et al. (2003) Cell 112, 41-50. PMID: 12526792

3. Yang, J. et al. (2005) The EMBO journal 24, 1-10. PMID: 15577939

4. Martínez-Ruiz, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8525-30. PMID: 15937123

5. Woodford, MR. et al. (2016) Nature communications 7, 12037. PMID: 27353360

6. Woodford, MR. et al. (2017) The EMBO journal 36, 3650-3665. PMID: 29127155

7. Pearl, LH. (2016) Biopolymers 105, 594-607. PMID: 26991466

8. Verma, S. et al. (2016) Biochimie 127, 227-40. PMID: 27295069

9. Khurana, N. et al. (2015) Frontiers in oncology 5, 100. PMID: 25973397

10. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-HSP90AA1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: PC-12 cell lysate
Lane 3: Hela cell lysate
Lane 4: MCF-7 cell lysate
Lane 5: Jurkat cell lysate
Lane 6: Lncap cell lysate
Lane 7: Raji cell lysate
Lane 8: Mouse brain lysate
Lane 9: Rat brain lysate

Reférences

Fiche technique

Anti-HSP90AA1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-HSP90AA1 Polyclonal Antibody (HY503014)

Aperçu

Images

Reférences

Fiche technique

SDS