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| カタログ番号 | HY503014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HSP90AA1 Polyclonal Antibody (HY503014) is a rabbit polyclonal antibody detecting HSP90AA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HSP90AA1 (Ser39-Asp193). | ||||||||
| ターゲット | LPS-associated protein 2, Heat shock protein HSP 90-alpha, HSPCA, HSP90A, HSP 86, Lipopolysaccharide-associated protein 2, HSP86, HSP90AA1, Heat shock 86 kDa, Renal carcinoma antigen NY-REN-38, LAP-2, HSPC1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07900 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Heat shock protein HSP 90-alpha (HSP90AA1) is a ~84 kDa protein. Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. 1. Forsythe, HL. et al. (2001) The Journal of biological chemistry 276, 15571-4. PMID: 11274138 2. Young, JC. et al. (2003) Cell 112, 41-50. PMID: 12526792 3. Yang, J. et al. (2005) The EMBO journal 24, 1-10. PMID: 15577939 4. Martínez-Ruiz, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8525-30. PMID: 15937123 5. Woodford, MR. et al. (2016) Nature communications 7, 12037. PMID: 27353360 6. Woodford, MR. et al. (2017) The EMBO journal 36, 3650-3665. PMID: 29127155 7. Pearl, LH. (2016) Biopolymers 105, 594-607. PMID: 26991466 8. Verma, S. et al. (2016) Biochimie 127, 227-40. PMID: 27295069 9. Khurana, N. et al. (2015) Frontiers in oncology 5, 100. PMID: 25973397 10. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-HSP90AA1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: PC-12 cell lysate
Lane 3: Hela cell lysate
Lane 4: MCF-7 cell lysate
Lane 5: Jurkat cell lysate
Lane 6: Lncap cell lysate
Lane 7: Raji cell lysate
Lane 8: Mouse brain lysate
Lane 9: Rat brain lysate
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