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| カタログ番号 | HT488014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ABCC5 Polyclonal Antibody (HT488014) is a rabbit polyclonal antibody detecting ABCC5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCC5 (Ala629-Gly847). | ||||||||
| ターゲット | ATP-binding cassette sub-family C member 5, 7.6.2.-, 7.6.2.2, Multi-specific organic anion transporter C, MOAT-C, Multidrug resistance-associated protein 5, SMRP, pABC11, ABCC5, MRP5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15440 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family C member 5 (ABCC5) is a ~160 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. 1. Jedlitschky, G. et al. (2000) The Journal of biological chemistry 275, 30069-74. PMID: 10893247 2. Wielinga, PR. et al. (2003) The Journal of biological chemistry 278, 17664-71. PMID: 12637526 3. Reid, G. et al. (2003) Molecular pharmacology 63, 1094-103. PMID: 12695538 4. Wielinga, P. et al. (2005) Cancer research 65, 4425-30. PMID: 15899835 5. de Wolf, CJ. et al. (2007) The FEBS journal 274, 439-50. PMID: 17229149 6. Jansen, RS. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 6601-6. PMID: 25964343 7. Jansen, RS. et al. (2015) The Journal of biological chemistry 290, 30429-40. PMID: 26515061 8. Wijnholds, J. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 7476-81. PMID: 10840050 9. Wielinga, PR. et al. (2002) Molecular pharmacology 62, 1321-31. PMID: 12435799 | ||||||||
| 注意事項 | For research use only. |
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