Anti-Human ABCC5 Polyclonal Antibody (HT488014)

Name: Anti-Human ABCC5 Polyclonal Antibody
Brand: abinScience
SKU: HT488014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HT488014

Описание

Anti-Human ABCC5 Polyclonal Antibody (HT488014) is a rabbit polyclonal antibody detecting ABCC5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human ABCC5 (Ala629-Gly847).

Цель

ATP-binding cassette sub-family C member 5, 7.6.2.-, 7.6.2.2, Multi-specific organic anion transporter C, MOAT-C, Multidrug resistance-associated protein 5, SMRP, pABC11, ABCC5, MRP5

Очистка

Purified by antigen affinity column.

Номер доступа

O15440

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

ATP-binding cassette sub-family C member 5 (ABCC5) is a ~160 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated.

1. Jedlitschky, G. et al. (2000) The Journal of biological chemistry 275, 30069-74. PMID: 10893247

2. Wielinga, PR. et al. (2003) The Journal of biological chemistry 278, 17664-71. PMID: 12637526

3. Reid, G. et al. (2003) Molecular pharmacology 63, 1094-103. PMID: 12695538

4. Wielinga, P. et al. (2005) Cancer research 65, 4425-30. PMID: 15899835

5. de Wolf, CJ. et al. (2007) The FEBS journal 274, 439-50. PMID: 17229149

6. Jansen, RS. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 6601-6. PMID: 25964343

7. Jansen, RS. et al. (2015) The Journal of biological chemistry 290, 30429-40. PMID: 26515061

8. Wijnholds, J. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 7476-81. PMID: 10840050

9. Wielinga, PR. et al. (2002) Molecular pharmacology 62, 1321-31. PMID: 12435799

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human ABCC5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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