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| カタログ番号 | HY429014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ACADM Polyclonal Antibody (HY429014) is a rabbit polyclonal antibody detecting ACADM in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Macaca fascicularis.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ACADM (Lys26-Asn421). | ||||||||
| ターゲット | MCADH, MCAD, ACADM, Medium chain acyl-CoA dehydrogenase, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P11310 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) is a ~46 kDa protein. Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16. 1. Bross, P. et al. (1990) The Journal of biological chemistry 265, 7116-9. PMID: 1970566 2. He, M. et al. (2011) Molecular genetics and metabolism 102, 418-29. PMID: 21237683 3. Kelly, DP. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9236-40. PMID: 2251268 4. Nandy, A. et al. (1996) Biochemistry 35, 12402-11. PMID: 8823175 5. Toogood, HS. et al. (2004) The Journal of biological chemistry 279, 32904-12. PMID: 15159392 6. Małecki, J. et al. (2015) The Journal of biological chemistry 290, 423-34. PMID: 25416781 | ||||||||
| 注意事項 | For research use only. |
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