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| カタログ番号 | HW543014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ACADSB (Thr58-Tyr432). | ||||||||
| ターゲット | 2-methyl branched chain acyl-CoA dehydrogenase, SBCAD, 2-MEBCAD, 2-methylbutyryl-CoA dehydrogenase, ACADSB, Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial, 2-methylbutyryl-coenzyme A dehydrogenase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P45954 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) is a ~47 kDa protein. Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug. 1. Gibson, KM. et al. (2000) Pediatric research 47, 830-3. PMID: 10832746 2. Andresen, BS. et al. (2000) American journal of human genetics 67, 1095-103. PMID: 11013134 3. Luís, PB. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 1155-60. PMID: 21430231 4. Rozen, R. et al. (1994) Genomics 24, 280-7. PMID: 7698750 | ||||||||
| 注意事項 | For research use only. |
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