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| カタログ番号 | HT441014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ACOT8 Polyclonal Antibody (HT441014) is a rabbit polyclonal antibody detecting ACOT8 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ACOT8 (Gly21-Leu319). | ||||||||
| ターゲット | Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, 3.1.2.1, 3.1.2.11, 3.1.2.2, 3.1.2.3, 3.1.2.5, Choloyl-coenzyme A thioesterase, 3.1.2.27, HIV-Nef-associated acyl-CoA thioesterase, Peroxisomal acyl-CoA thioesterase 2, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, hACTEIII, hTE, ACOT8, ACTEIII, PTE1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14734 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Acyl-coenzyme A thioesterase 8 (ACOT8) is a ~35 kDa protein. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. 1. Ishizuka, M. et al. (2004) Experimental cell research 297, 127-41. PMID: 15194431 2. Liu, LX. et al. (1997) The Journal of biological chemistry 272, 13779-85. PMID: 9153233 3. Watanabe, H. et al. (1997) Biochemical and biophysical research communications 238, 234-9. PMID: 9299485 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ACOT8 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
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