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| カタログ番号 | HY494014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ADH5 Polyclonal Antibody (HY494014) is a rabbit polyclonal antibody detecting ADH5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ADH5 (Met1-Ile374). | ||||||||
| ターゲット | ADHX, ADH5, FDH, Alcohol dehydrogenase class chi chain, Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase, FALDH, Glutathione-dependent formaldehyde dehydrogenase, Alcohol dehydrogenase 5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P11766 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Alcohol dehydrogenase class-3 (ADH5) is a ~39 kDa protein. Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation. 1. Engeland, K. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2491-4. PMID: 8460164 2. Collins, XH. et al. (2005) The Journal of biological chemistry 280, 33157-64. PMID: 16081420 3. Oka, Y. et al. (2020) Science advances 6. PMID: 33355142 | ||||||||
| 注意事項 | For research use only. |
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