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| カタログ番号 | HP903014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ADI1 Polyclonal Antibody (HP903014) is a rabbit polyclonal antibody detecting ADI1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ADI1 (Met1-Ala179). | ||||||||
| ターゲット | Sip-L, Acireductone dioxygenase (Fe(2+)-requiring), ADI1, ARD, 1, 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, MTCBP-1, Submergence-induced protein-like factor, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, Fe-ARD, MTCBP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BV57 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Acireductone dioxygenase (ADI1) is a ~21 kDa protein. Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. 1. Hirano, W. et al. (2005) Genes to cells : devoted to molecular & cellular mechanisms 10, 565-74. PMID: 15938715 2. Uekita, T. et al. (2004) The Journal of biological chemistry 279, 12734-43. PMID: 14718544 3. Yeh, CT. et al. (2001) Journal of virology 75, 11017-24. PMID: 11602742 | ||||||||
| 注意事項 | For research use only. |
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