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| カタログ番号 | HY053014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ADORA3 Polyclonal Antibody (HY053014) is a rabbit polyclonal antibody detecting ADORA3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ADORA3 (Leu270-Glu318). | ||||||||
| ターゲット | ADORA3, Adenosine receptor A3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0DMS8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Adenosine receptor A3 (ADORA3) is a ~36 kDa protein. G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection. Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels. Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway. In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus. 1. Cai, H. et al. (2024) Nature communications 15, 3252. PMID: 38627384 2. Zhang, L. et al. (2025) Nature communications 16, 7674. PMID: 40825947 3. Dougherty, C. et al. (1998) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 12, 1785-92. PMID: 9837869 4. Ogawa, A. et al. (2021) Molecular cell 81, 659-674.e7. PMID: 33472058 5. Oshima, HS. et al. (2024) Nature communications 15, 9294. PMID: 39511145 6. Bouma, MG. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 5400-8. PMID: 9164961 | ||||||||
| 注意事項 | For research use only. |
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