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| カタログ番号 | HB002013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1577 | ||||
| ターゲット | Beta-3 adrenoreceptor, Beta-3 adrenoceptor, B3AR, ADRB3, Beta-3 adrenergic receptor, ADRB3R | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P13945 | ||||
| RRID | Anti-Human ADRB3 Antibody (SAA1577) (abinScience Cat# HB002013, RRID:AB_3727338) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Beta-3 adrenergic receptor (ADRB3) is a ~43 kDa protein. G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. 1. Igawa, Y. et al. (1999) British journal of pharmacology 126, 819-25. PMID: 10188996 2. Emorine, LJ. et al. (1989) Science (New York, N.Y.) 245, 1118-21. PMID: 2570461 3. Candelore, MR. et al. (1996) Endocrinology 137, 2638-41. PMID: 8641219 4. Soeder, KJ. et al. (1999) The Journal of biological chemistry 274, 12017-22. PMID: 10207024 5. Gauthier, C. et al. (1998) The Journal of clinical investigation 102, 1377-84. PMID: 9769330 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ADRB3 Antibody (SAA1577)
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