

| Numéro de catalogue | HP615014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human AFF4 (Ser914-Lys1160). | ||||||||
| Cible | Major CDK9 elongation factor-associated protein, MCEF, Protein AF-5q31, ALL1-fused gene from chromosome 5q31 protein, AF5Q31, AFF4, AF4/FMR2 family member 4 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9UHB7 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | AF4/FMR2 family member 4 (AFF4) is a ~127 kDa protein. Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. | ||||||||
| Note | For research use only. |
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