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| カタログ番号 | HP163014 | ||||||||
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| 説明 |
Anti-Human AGTPBP1 Polyclonal Antibody (HP163014) is a rabbit polyclonal antibody detecting AGTPBP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Xenopus laevis, and Xenopus tropicalis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AGTPBP1 (Glu706-Cys1030). | ||||||||
| ターゲット | Cytosolic carboxypeptidase 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, ATP/GTP-binding protein 1, CCP1, AGTPBP1, KIAA1035, NNA1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UPW5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cytosolic carboxypeptidase 1 (AGTPBP1) is a ~138 kDa protein. Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis. 1. Berezniuk, I. et al. (2012) The Journal of biological chemistry 287, 6503-17. PMID: 22170066 2. Berezniuk, I. et al. (2013) The Journal of biological chemistry 288, 30445-30453. PMID: 24022482 3. Shashi, V. et al. (2018) The EMBO journal 37. PMID: 30420557 4. Ye, B. et al. (2018) Nature communications 9, 1261. PMID: 29593216 | ||||||||
| 注意事項 | For research use only. |
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