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| カタログ番号 | HT110014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human AKAP8 Polyclonal Antibody (HT110014) is a rabbit polyclonal antibody detecting AKAP8 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AKAP8 (Met1-Glu572). | ||||||||
| ターゲット | AKAP8, A-kinase anchor protein 8, AKAP95, AKAP-8, A-kinase anchor protein 95 kDa, AKAP 95 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43823 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | A-kinase anchor protein 8 (AKAP8) is a ~76 kDa protein. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. 1. Eide, T. et al. (1998) Experimental cell research 238, 305-16. PMID: 9473338 2. Collas, P. et al. (1999) The Journal of cell biology 147, 1167-80. PMID: 10601332 3. Steen, RL. et al. (2000) The Journal of cell biology 149, 531-6. PMID: 10791967 4. Eide, T. et al. (2002) EMBO reports 3, 426-32. PMID: 11964380 5. Arsenijevic, T. et al. (2004) The Biochemical journal 378, 673-9. PMID: 14641107 6. Li, Y. et al. (2006) Genes & development 20, 2566-79. PMID: 16980585 7. Gao, X. et al. (2012) Molecular biology of the cell 23, 503-15. PMID: 22130794 8. Eide, T. et al. (2003) The Journal of biological chemistry 278, 26750-6. PMID: 12740381 9. Jiang, H. et al. (2013) Nature structural & molecular biology 20, 1156-63. PMID: 23995757 10. Kamada, S. et al. (2005) Molecular and cellular biology 25, 9469-77. PMID: 16227597 | ||||||||
| 注意事項 | For research use only. |
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