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| カタログ番号 | HP973014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALKBH7 (Ser16-Cys221). | ||||||||
| ターゲット | Spermatogenesis-associated protein 11, ABH7, Alkylated DNA repair protein alkB homolog 7, ALKBH7, Spermatogenesis cell proliferation-related protein, SPATA11, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BT30 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RNA demethylase ALKBH7, mitochondrial is a ~24 kDa protein. RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism. 1. Zhang, LS. et al. (2021) Nature cell biology 23, 684-691. PMID: 34253897 2. Fu, D. et al. (2013) Genes & development 27, 1089-100. PMID: 23666923 | ||||||||
| 注意事項 | For research use only. |
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