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Anti-Human ALPK1 Polyclonal Antibody (HD668014)

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Aperçu
Numéro de catalogueHD668014
Description
Anti-Human ALPK1 Polyclonal Antibody (HD668014) is a rabbit polyclonal antibody detecting ALPK1. Suitable for Human.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human ALPK1 (Ser960-Thr1244).
Cible ALPK1, Alpha-protein kinase 1, Chromosome 4 kinase, EC:2.7.11.1, KIAA1527, LAK, Lymphocyte alpha-protein kinase
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès Q96QP1
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Alpha-protein kinase 1 (ALPK1) is a ~138 kDa protein. Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A.

1. Milivojevic, M. et al. (2017) PLoS pathogens 13, e1006224. PMID: 28222186
2. Zimmermann, S. et al. (2017) Cell reports 20, 2384-2395. PMID: 28877472
3. Zhou, P. et al. (2018) Nature 561, 122-126. PMID: 30111836
4. Kozycki, CT. et al. (2022) Annals of the rheumatic diseases 81, 1453-1464. PMID: 35868845
5. Snelling, T. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2313148120. PMID: 38060563
6. Lee, CP. et al. (2016) Scientific reports 6, 25740. PMID: 27169898
7. Heine, M. et al. (2005) The Journal of biological chemistry 280, 25637-43. PMID: 15883161
8. Williams, LB. et al. (2019) Genetics in medicine : official journal of the American College of Medical Genetics 21, 2103-2115. PMID: 30967659
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human ALPK1 Polyclonal Antibody

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