Anti-Human AMOTL2/LCCP Polyclonal Antibody (HP046014)

Name: Anti-Human AMOTL2/LCCP Polyclonal Antibody
Brand: abinScience
SKU: HP046014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
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Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP046014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human AMOTL2/LCCP (Ser540-Asp653).

Objetivo

LCCP, AMOTL2, Angiomotin-like protein 2, Leman coiled-coil protein, KIAA0989

Purificación

Purified by antigen affinity column.

Número de acceso

Q9Y2J4

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Angiomotin-like protein 2 (AMOTL2/LCCP) is a ~85 kDa protein. Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation. Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces. This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching.

1. Hildebrand, S. et al. (2017) Scientific reports 7, 9540. PMID: 28842668

2. Hwang, D. et al. (2021) Life science alliance 4. PMID: 34404733

3. Huang, H. et al. (2007) Development (Cambridge, England) 134, 979-88. PMID: 17293535

4. Zhao, B. et al. (2011) Genes & development 25, 51-63. PMID: 21205866

5. Kim, M. et al. (2016) EMBO reports 17, 64-78. PMID: 26598551

6. Lucci, V. et al. (2013) Gene 529, 300-6. PMID: 23911299

7. Proszynski, TJ. et al. (2013) Journal of cell science 126, 2225-35. PMID: 23525008

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human AMOTL2/LCCP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo