中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP046014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AMOTL2/LCCP (Ser540-Asp653). | ||||||||
| ターゲット | LCCP, AMOTL2, Angiomotin-like protein 2, Leman coiled-coil protein, KIAA0989 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y2J4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Angiomotin-like protein 2 (AMOTL2/LCCP) is a ~85 kDa protein. Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation. Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces. This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching. 1. Hildebrand, S. et al. (2017) Scientific reports 7, 9540. PMID: 28842668 2. Hwang, D. et al. (2021) Life science alliance 4. PMID: 34404733 3. Huang, H. et al. (2007) Development (Cambridge, England) 134, 979-88. PMID: 17293535 4. Zhao, B. et al. (2011) Genes & development 25, 51-63. PMID: 21205866 5. Kim, M. et al. (2016) EMBO reports 17, 64-78. PMID: 26598551 6. Lucci, V. et al. (2013) Gene 529, 300-6. PMID: 23911299 7. Proszynski, TJ. et al. (2013) Journal of cell science 126, 2225-35. PMID: 23525008 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
