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| カタログ番号 | HP196014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ANKRD27 (Met654-Ser902). | ||||||||
| ターゲット | ANKRD27, Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96NW4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ankyrin repeat domain-containing protein 27 (ANKRD27) is a ~116 kDa protein. May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. 1. Zhang, X. et al. (2006) Journal of cell science 119, 1053-62. PMID: 16525121 2. Wang, F. et al. (2008) Biochemical and biophysical research communications 372, 162-7. PMID: 18477474 3. Schäfer, IB. et al. (2012) Nature structural & molecular biology 19, 1300-9. PMID: 23104059 4. Burgo, A. et al. (2012) Developmental cell 23, 166-80. PMID: 22705394 5. Burgo, A. et al. (2009) EMBO reports 10, 1117-24. PMID: 19745841 6. Hesketh, GG. et al. (2014) Developmental cell 29, 591-606. PMID: 24856514 | ||||||||
| 注意事項 | For research use only. |
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