Anti-Human ANXA2 Recombinant Antibody (SAA2551) (HY297023)

Name: Anti-Human ANXA2 Recombinant Antibody (SAA2551)
Brand: abinScience
SKU: HY297023
Price: 126 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY297023

Reactividad de especies

Human

Aplicaciones

ELISA, IP

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA2551

Objetivo

ANX2, ANX2L4, ANXA2, Annexin A2, Annexin II, Annexin-2, CAL1H, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, LPC2D, Lipocortin II, PAP-IV, Placental anticoagulant protein IV, Protein I, p36

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P07355

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Annexin A2 (ANXA2) is a ~38 kDa protein. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation.

1. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458

2. Seidah, NG. et al. (2012) PloS one 7, e41865. PMID: 22848640

3. Ly, K. et al. (2014) The Journal of biological chemistry 289, 17732-46. PMID: 24808179

Nota

For research use only

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Imágenes