Anti-Human ANXA2 Recombinant Antibody (SAA2551) (HY297023)

Name: Anti-Human ANXA2 Recombinant Antibody (SAA2551)
Brand: abinScience
SKU: HY297023
Price: 126 USD
Availability: InStock

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20ug
50ug
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1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY297023

Reactivité des espèces

Human

Applications

ELISA, IP

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA2551

Cible

ANX2, ANX2L4, ANXA2, Annexin A2, Annexin II, Annexin-2, CAL1H, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, LPC2D, Lipocortin II, PAP-IV, Placental anticoagulant protein IV, Protein I, p36

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P07355

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Annexin A2 (ANXA2) is a ~38 kDa protein. Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation.

1. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458

2. Seidah, NG. et al. (2012) PloS one 7, e41865. PMID: 22848640

3. Ly, K. et al. (2014) The Journal of biological chemistry 289, 17732-46. PMID: 24808179

Note

For research use only

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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