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| カタログ番号 | HF867014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human AP2A1 Polyclonal Antibody (HF867014) is a rabbit polyclonal antibody detecting AP2A1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AP2A1 (Ile737-Phe977). | ||||||||
| ターゲット | AP-2 complex subunit alpha-1, Alpha1-adaptin, Adaptor protein complex AP-2 subunit alpha-1, 100 kDa coated vesicle protein A, Clathrin assembly protein complex 2 alpha-A large chain, ADTAA, CLAPA1, AP2A1, Adaptor-related protein complex 2 subunit alpha-1, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit, Alpha-adaptin A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95782 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | AP-2 complex subunit alpha-1 (AP2A1) is a ~107 kDa protein. Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. 1. Marcello, E. et al. (2013) The Journal of clinical investigation 123, 2523-38. PMID: 23676497 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-AP2A1 polyclonal antibody at 1μg/ml on various samples.
Lane 1: SKOV3 cell lysate
Lane 2: THP-1 cell lysate
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