Anti-Human APH1A Polyclonal Antibody (HP487024)

Name: Anti-Human APH1A Polyclonal Antibody
Brand: abinScience
SKU: HP487024
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HP487024

Descripción

Anti-Human APH1A Polyclonal Antibody (HP487024) is a rabbit polyclonal antibody detecting Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha; Presenilin-stabilization factor; APH1A; PSF; CGI-78; UNQ579/PRO1141 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant human APH1A (Trp53-Gln68&Tyr90-Ala118&Asp140-Leu158&Ser235-Asp265).

Objetivo

Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha; Presenilin-stabilization factor; APH1A; PSF; CGI-78; UNQ579/PRO1141

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q96BI3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

1. Lee, SF. et al. (2002) The Journal of biological chemistry 277, 45013-9. PMID: 12297508

2. Luo, WJ. et al. (2003) The Journal of biological chemistry 278, 7850-4. PMID: 12522139

3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021

5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335

7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546

8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874

9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human APH1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human APH1A Polyclonal Antibody (HP487024)

Vista general

Imágenes

Referencias

Datasheet

SDS