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| カタログ番号 | HP487024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human APH1A Polyclonal Antibody (HP487024) is a rabbit polyclonal antibody detecting Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha; Presenilin-stabilization factor; APH1A; PSF; CGI-78; UNQ579/PRO1141 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human APH1A (Trp53-Gln68&Tyr90-Ala118&Asp140-Leu158&Ser235-Asp265). | ||||||||
| ターゲット | Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha; Presenilin-stabilization factor; APH1A; PSF; CGI-78; UNQ579/PRO1141 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96BI3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). 1. Lee, SF. et al. (2002) The Journal of biological chemistry 277, 45013-9. PMID: 12297508 2. Luo, WJ. et al. (2003) The Journal of biological chemistry 278, 7850-4. PMID: 12522139 3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784 4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021 5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039 6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335 7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546 8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874 9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034 | ||||||||
| 注意事項 | For research use only |
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