

| Каталожный номер | HV404013 | ||||
|---|---|---|---|---|---|
| Реактивность видов | Human | ||||
| Применения | ELISA | ||||
| Хозяинский вид | Mouse | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG2a, kappa | ||||
| ID клона | SAA1754 | ||||
| Цель | APEL, Apelin, APJ endogenous ligand, APLN | ||||
| Уровень эндотоксинов | < 10 EU/mg | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | Q9ULZ1 | ||||
| RRID | Anti-Human APLN/Apelin Antibody (SAA1754) (abinScience Cat# HV404013, RRID:AB_3727515) |
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| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| Фон | Apelin (APLN) is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. 1. Habata, Y. et al. (1999) Biochimica et biophysica acta 1452, 25-35. PMID: 10525157 2. Scimia, MC. et al. (2012) Nature 488, 394-8. PMID: 22810587 3. Yue, Y. et al. (2022) Nature structural & molecular biology 29, 688-697. PMID: 35817871 4. Wang, WW. et al. (2024) Cell 187, 1460-1475.e20. PMID: 38428423 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human APLN/Apelin Antibody (SAA1754)



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