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| カタログ番号 | HP910014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ARHGAP10 (Asp392-Thr576). | ||||||||
| ターゲット | Graf-related protein 2, GTPase regulator associated with focal adhesion kinase 2, ARHGAP10, GRAF2, Rho GTPase-activating protein 10, Rho-type GTPase-activating protein 10 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | A1A4S6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Rho GTPase-activating protein 10 (ARHGAP10) is a ~89 kDa protein. GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. 1. Shibata, H. et al. (2001) Journal of biochemistry 130, 23-31. PMID: 11432776 2. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433 | ||||||||
| 注意事項 | For research use only. |
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