

| Numéro de catalogue | HW313014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human ARHGDIA Polyclonal Antibody (HW313014) is a rabbit polyclonal antibody detecting ARHGDIA in ELISA, IHC, WB. Suitable for Bovine, Human, Macaca fascicularis, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human ARHGDIA (Asn69-Asp204). | ||||||||
| Cible | Rho GDP-dissociation inhibitor 1, GDIA1, Rho GDI 1, Rho-GDI alpha, ARHGDIA | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P52565 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Rho GDP-dissociation inhibitor 1 (ARHGDIA) is a ~23 kDa protein. Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-ARHGDIA polyclonal antibody at 1μg/ml on various samples.
Lane 1: HL-60 cell lysate
Lane 2: NIH3T3 cell lysate
Lane 3: Mouse lung lysate
Lane 4: Rat lung lysate
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